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| Single-Season Strikeouts per 9IP Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts per 9IP | IP | Year | |
| 1. | Ernesto Mejias | 11.26 | 228.7 | 2008 | |
| 2. | Jack Smith | 10.97 | 237.0 | 2008 | |
| 3. | Jack Smith | 10.94 | 211.3 | 2009 | |
| 4. | Ernesto Mejias | 10.93 | 185.3 | 2009 | |
| 5. | Ernesto Mejias | 10.05 | 248.0 | 2007 | |
| 6. | Ronnie Nesmith | 10.02 | 211.0 | 2009 | |
| 7. | Victor McFaddin | 9.77 | 211.0 | 2007 | |
| 8. | Robert Welsch | 9.66 | 209.7 | 2008 | |
| 9. | Victor McFaddin | 9.36 | 218.3 | 2009 | |
| 10. | Ronnie Nesmith | 9.31 | 205.0 | 2008 | |
| 11. | Robert Welsch | 9.23 | 238.0 | 2007 | |
| 12. | Robert Welsch | 9.13 | 214.0 | 2009 | |
| 13. | Ruben Olmeda | 9.00 | 178.0 | 2007 | |
| 14. | Fidel Havana | 8.95 | 186.0 | 2009 | |
| 15. | Patrick Segars | 8.94 | 212.3 | 2009 | |
| 16. | David Jarvis | 8.86 | 256.0 | 2007 | |
| 17. | James Barton | 8.82 | 216.3 | 2008 | |
| 18. | Oswaldo Acuņa | 8.71 | 219.0 | 2007 | |
| 19. | Adan Gingras | 8.70 | 169.7 | 2007 | |
| 20. | James Barton | 8.57 | 216.3 | 2007 | |
| 21. | Ruben Olmeda | 8.48 | 165.7 | 2008 | |
| 22. | Fidel Havana | 8.46 | 211.7 | 2008 | |
| 23. | Adan Gingras | 8.29 | 193.3 | 2009 | |
| 24. | Felix Pedraza | 7.85 | 183.3 | 2008 | |
| 25. | Silvio Perez | 7.84 | 187.0 | 2009 | |
| 26. | John Moronta | 7.78 | 239.3 | 2007 | |
| 27. | David Jarvis | 7.78 | 223.3 | 2008 | |
| 28. | Silvio Perez | 7.66 | 233.7 | 2007 | |
| 29. | John Moronta | 7.63 | 270.0 | 2009 | |
| 30. | Michael Davis | 7.55 | 227.7 | 2007 | |
| 31. | Higinio Hernandez | 7.51 | 187.0 | 2007 | |
| 32. | Michael Davis | 7.50 | 242.3 | 2008 | |
| 33. | John Moronta | 7.47 | 257.7 | 2008 | |
| 34. | Dillon Crawford | 7.44 | 202.0 | 2008 | |
| 35. | Juan Martinez | 7.43 | 224.0 | 2007 | |
| 36. | Dillon Crawford | 7.41 | 226.0 | 2009 | |
| 37. | Dillon Crawford | 7.33 | 222.3 | 2007 | |
| 38. | John Murrin | 7.24 | 164.0 | 2007 | |
| 39. | David Jarvis | 6.92 | 213.3 | 2009 | |
| 40. | Guillermo Torres | 6.88 | 188.3 | 2007 | |
| 41. | Jim Lenahan | 6.88 | 208.0 | 2009 | |
| 42. | Higinio Hernandez | 6.71 | 166.3 | 2009 | |
| 43. | Adrian Pastrana | 6.70 | 169.3 | 2007 | |
| 44. | Angel Barbosa | 6.70 | 168.0 | 2007 | |
| 45. | Kenneth Robinson | 6.67 | 216.0 | 2008 | |
| 46. | Gregory Micco | 6.58 | 187.3 | 2009 | |
| 47. | David Hemphill | 6.56 | 201.7 | 2009 | |
| 48. | Walter Frost | 6.51 | 170.0 | 2007 | |
| 49. | Conrado Amezcua | 6.51 | 175.7 | 2009 | |
| 50. | Alvin Medina | 6.46 | 213.0 | 2008 | |
| 51. | Alvin Medina | 6.43 | 175.0 | 2007 | |
| 52. | Hector Ferrer | 6.42 | 218.7 | 2008 | |
| 53. | Hideki Suzuki | 6.36 | 225.0 | 2009 | |
| 54. | Hector Ferrer | 6.33 | 187.7 | 2009 | |
| 55. | David Hemphill | 6.25 | 191.7 | 2008 | |
| 56. | Alvin Medina | 6.20 | 194.7 | 2009 | |
| 57. | David Hemphill | 6.18 | 186.3 | 2007 | |
| 58. | Gregory Micco | 6.14 | 217.0 | 2007 | |
| 59. | Stephen Pope | 6.14 | 176.0 | 2007 | |
| 60. | John Flora | 6.11 | 201.7 | 2007 | |
| 61. | John Barrett | 6.06 | 178.3 | 2007 | |
| 62. | Paul Therrien | 6.04 | 219.0 | 2007 | |
| 63. | Telmo Cosenza | 6.01 | 247.0 | 2007 | |
| 64. | Bobby Green | 6.00 | 171.0 | 2008 | |
| 65. | Matthew Sanchez | 6.00 | 214.7 | 2007 | |
| 66. | Vernon Olguin | 5.94 | 230.3 | 2008 | |
| 67. | Guillermo Torres | 5.91 | 192.0 | 2008 | |
| 68. | Brandon Jarrett | 5.88 | 182.0 | 2007 | |
| 69. | John Porter | 5.88 | 272.3 | 2009 | |
| 70. | Brandon Jarrett | 5.86 | 201.3 | 2008 | |
| 71. | Guillermo Torres | 5.85 | 206.0 | 2009 | |
| 72. | Telmo Cosenza | 5.83 | 233.0 | 2008 | |
| 73. | John Suggs | 5.81 | 213.7 | 2007 | |
| 74. | Paul Therrien | 5.74 | 222.7 | 2008 | |
| 75. | John Flora | 5.72 | 209.3 | 2008 | |
| 76. | David Borges | 5.68 | 193.3 | 2008 | |
| 77. | Angel Barbosa | 5.62 | 192.3 | 2008 | |
| 78. | Carlos Leal | 5.61 | 186.0 | 2008 | |
| 79. | Carlos Leal | 5.60 | 220.3 | 2009 | |
| 80. | Jim Lenahan | 5.56 | 205.7 | 2007 | |
| 81. | Robert Amundson | 5.55 | 202.7 | 2009 | |
| 82. | Joshua Grothe | 5.53 | 224.7 | 2007 | |
| 83. | Fredrick Planas | 5.53 | 198.7 | 2009 | |
| 84. | James Varnell | 5.47 | 177.7 | 2009 | |
| 85. | Jermaine Spates | 5.46 | 199.3 | 2008 | |
| 86. | Telmo Cosenza | 5.43 | 200.7 | 2009 | |
| 87. | Winfred Lee | 5.40 | 195.0 | 2007 | |
| 88. | Francisco Graziano | 5.39 | 177.0 | 2008 | |
| 89. | John Barrett | 5.35 | 215.3 | 2009 | |
| 90. | Marvin Hawkins | 5.33 | 192.7 | 2007 | |
| 91. | Man Mattia | 5.31 | 215.3 | 2008 | |
| 92. | Timothy Houston | 5.27 | 184.3 | 2007 | |
| 93. | Edson Paredes | 5.26 | 166.0 | 2008 | |
| 94. | Winfred Lee | 5.24 | 192.3 | 2009 | |
| 95. | Paul Therrien | 5.22 | 243.3 | 2009 | |
| 96. | Albert Martineau | 5.20 | 190.3 | 2008 | |
| 97. | Byron Hernandez | 5.20 | 220.0 | 2008 | |
| 98. | Garret Reyes | 5.18 | 215.3 | 2009 | |
| 99. | Albert Martineau | 5.18 | 233.0 | 2009 | |
| 100. | Brandon Jarrett | 5.10 | 178.3 | 2009 |
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