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| Single-Season At-Bats Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | At-Bats | PA | Year | Career Leaderboard |
| 1. | Carlos Sanchez | 672 | 710 | 2007 | |
| 2. | Martin Hunt | 652 | 715 | 2007 | |
| 3. | Bruno Ayo | 651 | 688 | 2008 | |
| 4. | Darnell Anderson | 646 | 720 | 2007 | |
| 5. | Robert Crawford | 635 | 689 | 2009 | |
| 6. | Joel Steverson | 634 | 676 | 2008 | |
| Phillip Oneill | 634 | 699 | 2007 | ||
| 8. | Miguel Valdes | 633 | 706 | 2008 | |
| 9. | Robert Crawford | 632 | 679 | 2007 | |
| 10. | Francisco Zamorano | 631 | 663 | 2007 | |
| 11. | Ryan Santoyo | 628 | 695 | 2008 | |
| Alfredo Leyva | 628 | 680 | 2007 | ||
| 13. | Darnell Anderson | 627 | 693 | 2009 | |
| William Byford | 627 | 677 | 2009 | ||
| John Carstarphen | 627 | 659 | 2008 | ||
| 16. | Robert Davis | 624 | 677 | 2008 | |
| Carlos Sanchez | 624 | 660 | 2008 | ||
| 18. | Roger Sands | 623 | 711 | 2009 | |
| 19. | Ronnie Obannon | 622 | 664 | 2009 | |
| Julian Benny | 622 | 662 | 2008 | ||
| 21. | Karl Goodwin | 619 | 675 | 2008 | |
| 22. | Francisco Zamorano | 617 | 655 | 2009 | |
| 23. | Ronnie Obannon | 616 | 684 | 2008 | |
| Travis Villa | 616 | 662 | 2008 | ||
| Alfredo Leyva | 616 | 656 | 2008 | ||
| Kevin Guevara | 616 | 683 | 2007 | ||
| 27. | Willy Emerson | 615 | 668 | 2009 | |
| 28. | Travis Villa | 614 | 655 | 2007 | |
| 29. | Steffen McBride | 613 | 680 | 2009 | |
| David Witte | 613 | 695 | 2007 | ||
| Michael Winnie | 613 | 661 | 2007 | ||
| 32. | Ramon Silvas | 612 | 672 | 2007 | |
| 33. | John Chaudhry | 611 | 673 | 2008 | |
| 34. | Joel Steverson | 610 | 651 | 2007 | |
| 35. | Roger Sands | 609 | 697 | 2008 | |
| Julio Velazquez | 609 | 685 | 2007 | ||
| 37. | Valentin Rivero | 607 | 647 | 2009 | |
| Bill Partlow | 607 | 641 | 2007 | ||
| 39. | John Carstarphen | 604 | 647 | 2009 | |
| Joshua Costillo | 604 | 662 | 2007 | ||
| 41. | Alonzo Sanchez | 603 | 652 | 2009 | |
| Anthony Ivy | 603 | 639 | 2007 | ||
| 43. | Bruno Martinez | 601 | 646 | 2008 | |
| 44. | Jacinto Alva | 600 | 662 | 2009 | |
| 45. | Miguel Valdes | 599 | 660 | 2007 | |
| 46. | Sheldon Thomas | 598 | 653 | 2008 | |
| 47. | John Ofarrell | 597 | 657 | 2009 | |
| John Ofarrell | 597 | 678 | 2008 | ||
| Victor Bufkin | 597 | 670 | 2007 | ||
| 50. | Bruno Ayo | 596 | 662 | 2007 | |
| 51. | Albert Espinosa | 595 | 631 | 2009 | |
| 52. | Travis Villa | 594 | 649 | 2009 | |
| 53. | Wallace Ingalls | 593 | 648 | 2008 | |
| Ryan Santoyo | 593 | 669 | 2007 | ||
| 55. | Matthew Parmley | 592 | 630 | 2008 | |
| 56. | Joey Kimmons | 591 | 649 | 2009 | |
| Davor Mendoza | 591 | 657 | 2008 | ||
| 58. | Minoru Kenzan | 590 | 634 | 2009 | |
| Andy Woodrum | 590 | 662 | 2008 | ||
| Robert Davis | 590 | 657 | 2007 | ||
| Jose Baeza | 590 | 650 | 2007 | ||
| 62. | Julio Velazquez | 588 | 683 | 2009 | |
| Ronaldo Florez | 588 | 636 | 2009 | ||
| 64. | Benito Jonas | 587 | 642 | 2009 | |
| Asdrubal Ibaņez | 587 | 644 | 2007 | ||
| 66. | Jose Henriquez | 586 | 626 | 2008 | |
| 67. | Robert Zeigler | 585 | 623 | 2007 | |
| 68. | Johnny Bristow | 583 | 656 | 2009 | |
| Julian Benny | 583 | 636 | 2009 | ||
| Valentin Rivero | 583 | 630 | 2008 | ||
| 71. | Robert Davis | 582 | 641 | 2009 | |
| 72. | Douglas Brewer | 581 | 620 | 2009 | |
| Robert Gallant | 581 | 673 | 2007 | ||
| Karl Goodwin | 581 | 642 | 2007 | ||
| 75. | Steven Johnson | 580 | 683 | 2009 | |
| Robert Crawford | 580 | 640 | 2008 | ||
| 77. | Jose Baeza | 579 | 645 | 2008 | |
| 78. | Matthew Burleigh | 578 | 637 | 2008 | |
| Anthony Ivy | 578 | 619 | 2008 | ||
| Davor Mendoza | 578 | 663 | 2007 | ||
| 81. | Phillip Oneill | 577 | 659 | 2008 | |
| 82. | Jose Henriquez | 576 | 612 | 2009 | |
| 83. | Davor Mendoza | 574 | 649 | 2009 | |
| John Chaudhry | 574 | 640 | 2007 | ||
| 85. | Andy Woodrum | 573 | 641 | 2009 | |
| Dean Defilippo | 573 | 629 | 2009 | ||
| 87. | Jimmy Vedder | 572 | 709 | 2009 | |
| 88. | Clint Bellomy | 571 | 617 | 2009 | |
| 89. | Bruce Sanroman | 570 | 622 | 2009 | |
| 90. | Tim Pletcher | 569 | 641 | 2009 | |
| Ramon Silvas | 569 | 637 | 2009 | ||
| Carlos Farias | 569 | 597 | 2009 | ||
| Floyd Stell | 569 | 656 | 2008 | ||
| Bill Partlow | 569 | 612 | 2008 | ||
| Floyd Stell | 569 | 665 | 2007 | ||
| Santiago Santacruz | 569 | 603 | 2007 | ||
| 97. | Joel Polanco | 568 | 619 | 2009 | |
| Steffen McBride | 568 | 625 | 2008 | ||
| Clint Bellomy | 568 | 609 | 2007 | ||
| 100. | Willy Emerson | 567 | 600 | 2007 |
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